Lisa Lisette (Rachel McAdams) is an executive at a five-star hotel. She received a notification from her family that her elderly grandmother had passed away. In order to rush back to attend her grandmother's funeral without affecting her work, she was afraid of flying and had to take a red-eye flight at night. At the airport, Lisa meets an attractive man, Jackson Lipno (Cillian Murphy), and the two hit it off and they hit it off. Coincidentally, the two sat next to each other on the plane. But when the plane took off, Jackson suddenly changed his face. He told Lisa viciously that their organization had kidnapped her father. In order to convince Lisa, he took out Lisa's father's wallet. He wants Lisa to obey his orders or kill her father. It turned out that the Jackson organization planned to assassinate a senior official of the Ministry of Security, and the hotel where the senior official stayed was the hotel where Lisa worked, and he needed Lisa's cooperation. At an altitude of 3,000 feet, Lisa had nowhere to escape. In order to protect her father, she fought wits with Jackson, and she couldn't get rid of his entanglement until she returned to the ground